Research

Professional Activities – Research (with sample publications selected from over 400)

1. Human Blood Coagulation System: After Factor 5 (Ac-globulin) was discovered
Stability of prothrombin and Ac-globulin in stored human plasma as influenced by conditions of storage. Am J Physiol. 1948; 154:122-133.

2. Wegener’s Granulomatosis – Diagnostic Criteria, Clinical course, Therapeutic challenges.
Am J Med. 1954; 17:168-179.

3. Ammonia toxicity with amino acid infusions
Toxicity and blood ammonia rise resulting from intravenous amino acid administration in man: The protective effect of L-arginine. J Clin Invest. 1957; 36:1647-1655.

4. Introduction of Plasmapheresis therapy for Hyperviscosity Syndromes
– Treatment of Waldenstrom’s macroglobulinemia by plasmapheresis. N Engl J Med. 1960;
263:574-579
– Serum hyperviscosity syndromes. JAMA. 1965 May 10; 192:464-467.

5. Human Immunoglobulin System
a. Discovery of IgD
– A new class of human immunoglobulins: II. Normal serum IgD. J Exp Med. 1965; 121:185-199.
– Metabolism of human immunoglobulin D (IgD). J Clin Invest. 1966; 45:1467-1478.
b. Identification of IgG subclasses
– Subclasses of human gamma2-globulins: (IgG) based on differences in the heavy polypeptide chains. Science. 1964; 146:400-402.
– Notation for human immunoglobulin subclasses. J Immunol. 1967 Aug; 99(2):465.
c. Production and Metabolism
– Immunoglobulin synthesis in vitro by established human cell lines. Science. 1966 May 27; 152(726):1259-1261.
– Limited periods of gene expression in immunoglobulin-synthesizing cells. Science. 1969 Jun; 164(887):1524-1525.

d. Quantitative Methods: Plasma Ig Levels in Disease
– Quantitative determination of 6.6S gamma-globulins, beta2A-globulins and gamma1-macroglobulins in human serum. J Immunol. 1963; 91:597-603.
– Immunoglobulin changes in disease: Quantitation of heavy polypeptide chain classes, IgG, IgA and IgM, and light polypeptide chain types IgK (Type I) and IgL (Type II). J Clin Invest. 1965; 44:1778-1787.

e. Genetic Studies
– Gm factors in normal gamma globulin fractions, myeloma proteins and macroglobulins. J Natl Cancer Inst. 1961; 27:973.
– Em and Inv factors in subclasses of human IgG. J Exp Med. 1965; 122:1087-1102.

6. Murine Immunoglobulin System
a. Identification of major murine Immunoglobulin Classes and Subclasses
– The immunoglobulins of mice: I. Four major classes of immunoglobulins: 7S gamma2, 7S gamma1, gamma1A (beta 2A) and 18Sgamma 1M-globulins. J Exp Med. 1964; 120:223-242.
– The immunoglobulins of mice: II. Two subclasses of mouse 7S gamma2-globulins: gamma2A and gamma2B-globulins. J Exp Med. 1964; 120:243-251.
– The immunoglobulins of mice. VI. Response to immunization. J Immunol. 1965; 95:781-790.

b. Relation of structure to function
– Heterologous and homologous skin sensitizing activity of mouse 7S1 and 7S2-globulins. Nature. 1965; 206:730-731.
– The immunoglobulins of mice. V. The metabolic (catabolic) properties of five immunoglobulin classes. J Exp Med. 1965; 122:41-58.

c. Regulation of IgG plasma levels
– Factors controlling serum gamma-globulin concentration. J Exp Med. 1963; 118:845-868.
– Gamma globulin metabolism in germ-free mice. J Immunol. 1964; 93:81-87. Fahey JL and Barth WF. The immunoglobulins of mice. IV. Serum immunoglobulin changes following birth. Proc Soc Exp Biol and Med. 1965; 118:596-600.

d. Murine Myeloma and Bence Jones protein
– Immunological studies of twenty mouse myeloma proteins: Evidence for two groups of proteins similar to gamma and beta-2A globulins in man. J Exp Med. 1961; 144:385-398.
– Formation of Bence Jones protein and myeloma protein in vitro. Biochem J. 1961; 80:261-268.

e. Studies of murine plasmacytomas (multiple myeloma)
– Abnormal serum protein and bone destruction in a transmissible mouse plasma cell neoplasm (multiple myeloma). Proc Soc Exp Biol and Med. 1957; 94:327-333.
– Studies on eight transplantable plasma-cell neoplasms of mice. J Natl Cancer Inst. 1960; 24:1153-1165.
– Effect of transplatable plasma cell tumors on antibody response in mice. Immunology. 1962; 5:110-115.

7. AIDS
a. Initial Discovery – Identified characteristic T cell changes and lymphocyte subset deficiencies Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: Evidence for a new severe acquired cellular Immunodeficiency. N. Engl. J. Med. 1981; 305:1425-1431.

b. Immunopathogenesis including immune activation in AIDS
– Quantitative changes in Th and Ts lymphocyte subsets that distinguish AIDS syndrome from other immune subset disorders. Am J Med. 1984; 76:95-100.
– Serum neopterin changes in HIV-infected subjects: Indicators of significant pathology, CD4 T cell changes and development of AIDS. J Acq Immun Def Synd. 1989, 2:70-76.
– The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Eng J Med. 1990; 322:166-172.
– Acute lymphoid changes and ongoing immune activation in SIV infection. J Acquir Immun Defic Syndr. 1992; 5:391-399.

c. Epidemiology with MultiCenter AIDS Cohort Study (MACS)
– Predictors of clinical AIDS in young homosexual men in a high-risk area. Intl J Epi. 1987; 16(2):271-276.
– Patterns of CD4 T cell changes after HIV-1 infection indicate the existence of a codeterminant of AIDS. J Acquir Immun Defic Syndr. 1988; 1(4):390-395.
– Cytokines, plasma immune activation markers and clinically relevant surrogate markers in Human Immunodeficiency Virus infection. Clin Diagn Lab Immunol. 1998; 5: 597-603.

d. Therapy Studies in association with AIDS Clinical Trial Group (ACTG)
– The effect of zidovudine treatment on serum neopterin and beta-2 microglobulin levels in mildly symptomatic, HIV type 1 seropositive individuals. J Acquir Immun Defic Syndr. 1992; 5:215-221.
– Thalidomide for the treatment of oral aphthous ulcers in patients with Human Immunodeficiency Virus infection. N Engl J Med. 1997 May 22; 336(21):1487-1493.
– The Virologic, Immunologic and Clinical Effects of Interleukin-2 with Potent Antiretroviral Therapy in Patients with Moderately Advanced HIV Infection: A Randomized Controlled Clinical Trial-ACTG 328. Arch Int Med, 2007, March 26; 167:597-605.

8. Nervous System-Immune System Interactions including Psychoneuroimmunology
– Repeated bereavement, depressed mood and immune parameters in HIV seropositive and seronegative homosexual men. Health Psychol. 1994; 13(1):14-24.
– Immunological and physiological changes associated with induced positive and negative mood. Psychosomatic Medicine. 1994; 56:499-511.
– Psychological Risk Factors for HIV Pathogenesis: Mediation by the Autonomic Nervous System. Biol Psychiatry. 2003 Dec 15; 54(12):1444-56.
– Shaking up Immunity (Earthquake). Psychosomatic Medicine. 1997; 59:114-127.
– T Cell Homeostasis in Breast Cancer Survivors with Persistent Fatigue. J Natl Cancer Institute. 2003, 95:1165-1168
– A structural psychiatric intervention for cancer patient changes over time in immunological Measures. Arch Gen Psychiatry. 1990; 9:71:80.
– Pituitary-Adrenal-Immune systems in normal subject and in patients with anorexia nervosa, Psychoneuroendocrinology. 1991; 16:423-432.

9. Clinical Laboratory Immunology
– Need for an External Proficiency Testing Program for Cytokines, Chemokines and Plasma Markers of Immune Activation. Clin Diag Lab Immunol. 2000; 7(4):540-548.
– The Impact of the International Program for Quality Assessment and Standardization for Immunological Measures Relevant to HIV/AIDS: QASI Progam, Clinical Cytometry. 2002 April 15; 50(2):111-116.

10. Idiopathic CD4 T cell Lymphocytopenia Clinical Immunology. 2001, 99:298-304.